Hormonal
Achieving and maintaining diabetes remission (HbA1c <48 mmol/mol off glucose-lowering medications) is associated with a significantly lower incidence of Major Adverse Diabetic Events (MADE) compared to those not in remission.
Achieving diabetes remission is not just about feeling better; it actively protects your kidneys, eyes, and nerves from long-term damage. By maintaining remission through weight loss and lifestyle changes, you significantly lower your risk of serious diabetic complications.
Table S9: In Remission at 1 Year... MADE Est (CI), p-value Yes: 0.7 (0.4, 1.0), p=0.076P; No: 1.0 (0.5, 1.1), p=0.13NB. Table S13: MADE Est (CI), p-value In Remission at 1 Year Yes: 0.6 (0.4, 1.0), p=0.034NB.
Why this rating
Randomized controlled trial extension study with long-term follow-up showing statistically significant reduction in MADE for those in remission.
Source
5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study
Michael EJ Lean et al. · The Lancet Diabetes & Endocrinology · 2024
DOI 10.1016/s2213-8587(23)00385-6
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