Energy balance
Hypocaloric diets reduce the secretion of leptin, TNF-alpha, IL-6, and IL-8 from adipose tissue, but do not alter the secretion of adiponectin or PAI-1, regardless of whether the diet is low-fat/high-carbohydrate or moderate-fat/moderate-carbohydrate.
If you are obese and lose weight through a caloric deficit, your body will likely reduce the secretion of leptin and inflammatory cytokines (TNF-alpha, IL-6, IL-8) from fat tissue. However, do not expect your adiponectin or PAI-1 secretion from fat tissue to change with moderate weight loss. The specific type of diet (low-fat vs. moderate-fat) matters less than the total calorie reduction for these specific markers.
In conclusion, moderate caloric restriction but not macronutrient composition influences the production and secretion of adipose tissue–derived proteins during weight reduction, leptin being the most sensitive and adiponectin and PAI-1 the least sensitive.
Why this rating
Randomized controlled trial with objective tissue biopsies and multiple assays, though the sample size is moderate (n=40) and duration is short (10 weeks).
Source
Effects of Different Hypocaloric Diets on Protein Secretion From Adipose Tissue of Obese Women
Elisabet Arvidsson et al. · Diabetes · 2004
DOI 10.2337/diabetes.53.8.1966
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