Energy balance
Meal replacement diets significantly reduce oxidative stress (measured by urine lipid peroxides) during weight maintenance compared to food-based diets, independent of the magnitude of weight loss.
If you are concerned about long-term health markers like oxidative stress, a structured meal replacement diet may offer additional benefits beyond just weight loss, specifically in reducing oxidative stress markers during the maintenance phase.
At week 40, ULP levels in the MD group decreased a mean of 1.3 micromol/g creatinine (17.5%), compared to 0.2 micromol/g creatinine (5.4%) among the FB group... which represented a significant difference between groups (Mann Whitney U = 145, Z = -2.07, p = 0.04)
Why this rating
RCT design, but the biomarker (ULP) is less standard than CRP or lipid panels, and the effect was only significant at week 40.
Source
Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial
Lisa Davis et al. · Nutrition Journal · 2010
DOI 10.1186/1475-2891-9-11
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