Research

Energy balance

Combining a very-low-energy diet (VLED, <800 kcal/day) with a behavioral weight loss program produces significantly greater long-term weight loss (3.9 kg at 12 months) compared to a behavioral program alone, with benefits maintained up to 60 months.

If you are overweight or obese, adding a very-low-energy diet (under 800 calories a day, typically liquid or meal replacements) to a standard behavioral weight loss program (like counseling or support groups) will help you lose more weight in the long run (up to 5 years) than just the behavioral program alone. The diet is safe for most people, with side effects being mostly minor (like tiredness or hair thinning) and serious issues being rare. You should discuss this with a healthcare provider to ensure it's appropriate for you, especially if you have other health conditions.

GoodSupportsHIGH confidence
Compared with a behavioural programme alone, VLEDs combined with a behavioural programme achieved −3.9 kg [95% confidence interval (CI) −6.7 to −1.1] at 1 year. The difference at 24 months was −1.4 kg (95%CI −2.6 to −0.2) and at 38–60 months was −1.3 kg (95%CI −2.9 to 0.2).
Helen M. Parretti et al. · Obesity Reviews · 2016

Why this rating

Systematic review and meta-analysis of 12 RCTs, though some heterogeneity and loss-to-follow-up imputation methods (BOCF) are noted.

Source

Clinical effectiveness of very‐low‐energy diets in the management of weight loss: a systematic review and meta‐analysis of randomized controlled trials

Helen M. Parretti et al. · Obesity Reviews · 2016

DOI 10.1111/obr.12366

Meta-analysis · 12 studiesCited 111×
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DOI resolved against Crossref · corpus check 2026-06-10

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