Research

Mixed

Adherence to a Spanish Ketogenic Mediterranean Diet (SKMD) for 12 weeks significantly reduces body weight, BMI, systolic and diastolic blood pressure, total cholesterol, LDL, triglycerides, and fasting glucose, while increasing HDL in obese adults.

Follow a Spanish Ketogenic Mediterranean Diet for 12 weeks. Eat unlimited calories but restrict carbohydrates to under 30g daily (from green vegetables/salads). Include at least 30ml of virgin olive oil and 200-400ml of red wine daily. Prioritize fish for protein. Take a daily multivitamin and calcium supplement. Expect significant weight loss and improved blood markers without needing to count calories.

ModerateSupportsMEDIUM confidence
There was an extremely significant (p < 0.0001) reduction in body weight (108.62 kg→ 94.48 kg), body mass index (36.46 kg/m2→31.76 kg/m2), systolic blood pressure (125.71 mmHg→109.05 mmHg), diastolic blood pressure (84.52 mmHg→ 75.24 mmHg), total cholesterol (208.24 mg/dl→186.62 mg/dl), triacylglicerols (218.67 mg/dl→113.90 mg/dl) and glucose (109.81 mg/dl→ 93.33 mg/dl).
Joaquín Pérez-Guisado et al. · Nutrition Journal · 2008

Why this rating

Small sample size (n=31), lack of control group, and short duration limit generalizability.

Source

Spanish Ketogenic Mediterranean diet: a healthy cardiovascular diet for weight loss

Joaquín Pérez-Guisado et al. · Nutrition Journal · 2008

DOI 10.1186/1475-2891-7-30

cohort · n=31Cited 83×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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