Research
Energy balance
Caloric restriction (30-40% reduction) extends mean and maximal lifespan and delays age-related diseases in nonhuman primates, suggesting similar effects in humans.
Caloric restriction of 30-40% significantly extends lifespan and reduces disease risk in primates, with strong evidence in rodents and preliminary evidence in monkeys. While likely beneficial for humans, strict adherence is difficult, suggesting a need for alternative strategies (mimetics).
GoodSupportsHIGH confidence
reduction in caloric intake by 30 – 40% from ad libitum levels leads to a significant extension of mean and maximal lifespan in a variety of short-lived species... Studies in longer-lived species, specifically rhesus and squirrel monkeys, have been underway since the late 1980s... suggesting that the effect of CR on aging is universal across species and that this nutritional paradigm will have similar effects in humans.
Why this rating
Strong evidence in rodents and preliminary but consistent data in primates; no conclusive human lifespan data yet.
Source
Caloric restriction and aging in primates: Relevance to humans and possible CR mimetics
Mark A. Lane et al. · Microscopy Research and Technique · 2002
DOI 10.1002/jemt.10214
narrative_reviewCited 81×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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