Energy balance
Ipragliflozin treatment for 24 weeks in type 2 diabetes patients reduces body weight primarily through fat mass loss while preserving total muscle mass and bone mineral content.
If you have type 2 diabetes and are already using insulin, adding 50mg of ipragliflozin daily for 24 weeks can help you lose about 2.8 kg of body weight. This weight loss comes mostly from fat, and your overall muscle mass and bone strength are likely to stay the same, which is important for maintaining strength and health.
Ipragliflozin treatment for 24 weeks resulted in reduced BW, mainly from fat mass loss. Muscle mass and bone mineral content were maintained.
Why this rating
Randomized controlled trial with adequate sample size for the primary endpoint, though open-label design is a limitation.
Source
Ipragliflozin, a sodium–glucose cotransporter 2 inhibitor, reduces bodyweight and fat mass, but not muscle mass, in Japanese type 2 diabetes patients treated with insulin: A randomized clinical trial
Hideka Inoue et al. · Journal of Diabetes Investigation · 2018
DOI 10.1111/jdi.12985
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