Research

Energy balance

Intermittent fasting for two consecutive days per week (IF2-P) produces significantly greater weight loss and waist circumference reduction than fasting for one day per week (IF1-P), despite both groups consuming matched total weekly energy intake and expenditure.

If you are overweight or obese, trying intermittent fasting for two consecutive days a week (like 26:2 or 60:168 patterns) may yield better weight loss results than fasting for just one day, even if you eat the same total amount of food over the week. Ensure your fasting days are nutrient-dense and low-sugar, and your feeding days include adequate protein (30-35% of calories) to preserve muscle mass.

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However, IF2-P resulted in significantly greater reductions in body weight (-29%) and waist circumference (-38%) compared to IF1-P (p < 0.05)... despite similar weekly total EI (IF1-P, 9058 ± 692 vs. IF2-P, 8389 ± 438 kcals/week; p = 0.79), and EE (~ 300 kcals/day; p = 0.90).
Paul J. Arciero et al. · Nutrition Journal · 2022

Why this rating

Randomized controlled trial with matched energy intake, though sample size is small (n=20).

Source

Intermittent fasting two days versus one day per week, matched for total energy intake and expenditure, increases weight loss in overweight/obese men and women

Paul J. Arciero et al. · Nutrition Journal · 2022

DOI 10.1186/s12937-022-00790-0

rct · n=20Cited 44×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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