Macro partitioning
A high-protein/low-carbohydrate (HP) diet provides superior metabolic improvement (glucose, insulin, HOMA-IR, lipids) compared to a standard hypocaloric diet, regardless of FTO genotype.
If you are obese and have the FTO variant, switching to a high-protein, lower-carbohydrate diet (approx. 33% carbs) will improve your blood sugar and cholesterol markers more effectively than a standard low-calorie diet, even if the total weight loss is similar.
With the HP diet and in both genotype groups, glucose, insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, triglycerides and low-density lipoprotein (LDL) decreased. With the S diet, total cholesterol and LDL decreased.
Why this rating
RCT design with clear biochemical measurements and statistical reporting.
Source
Effects of a High-Protein/Low-Carbohydrate Diet versus a Standard Hypocaloric Diet on Weight and Cardiovascular Risk Factors: Role of a Genetic Variation in the rs9939609 <b><i>FTO</i></b> Gene Variant
Daniel Antonio de Luis et al. · Lifestyle Genomics · 2015
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