Mixed
Carriers of the A allele of the FTO rs9939609 polymorphism experience significantly greater weight loss and fat mass reduction than TT genotype carriers when following either a high-protein/low-carbohydrate diet or a standard hypocaloric diet.
If you carry the A allele of the FTO gene, strict adherence to a hypocaloric diet (whether high-protein or standard) will likely result in greater weight loss than it does for people without this variant. Do not let the 'obesity gene' label discourage you; your biology may actually favor weight loss when you create a caloric deficit.
Weight loss was better in A allele carriers than noncarriers... With the HP diet, BMI (–1.9 ± 1.2 vs. –2.10 ± 1.8; p < 0.05), weight (–6.5 ± 2.1 vs. –10.1 ± 4.1 kg; p < 0.05), fat mass (–3.9 ± 3.2 vs. –6.0 ± 3.4 kg; p < 0.05) and waist circumference (–5.7 ± 5.0 vs. –9.9 ± 5.5 cm; p < 0.05) decreased in both genotype groups (TT vs. AT + AA).
Why this rating
Randomized controlled trial with a large sample size (n=195) and clear statistical significance, though limited to a specific demographic (obese adults).
Source
Effects of a High-Protein/Low-Carbohydrate Diet versus a Standard Hypocaloric Diet on Weight and Cardiovascular Risk Factors: Role of a Genetic Variation in the rs9939609 <b><i>FTO</i></b> Gene Variant
Daniel Antonio de Luis et al. · Lifestyle Genomics · 2015
DOI 10.1159/000441142
Related findings · Mixed
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