Energy balance
In healthy, normal-weight young adults, 5:2 intermittent energy restriction (IER) produces equivalent weight loss and postprandial metabolic responses to continuous energy restriction (CER), but yields superior improvements in fasting blood glucose and fasting subjective appetite scores.
If you are a healthy, normal-weight individual looking to lose weight, 5:2 intermittent fasting is just as effective as eating slightly less every day. You will lose the same amount of weight and see similar improvements in how your body handles food after meals. However, 5:2 fasting may offer a slight edge in lowering your fasting blood sugar and reducing hunger feelings when you wake up, which might help with long-term compliance for some people.
There were no significant differences in postprandial insulinaemic, glycaemic or appetite responses between treatments. However, 5:2 IER resulted in greater improvements in fasting blood glucose, and beneficial changes in fasting subjective appetite ratings.
Why this rating
Randomized controlled trial with objective metabolic measures, though limited by a small sample size (n=16) and short duration (2 weeks).
Source
Effects of intermittent (5:2) or continuous energy restriction on basal and postprandial metabolism: a randomised study in normal-weight, young participants
Yang-Fan Gao et al. · European Journal of Clinical Nutrition · 2021
DOI 10.1038/s41430-021-00909-2
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