Research

Energy balance

In healthy, normal-weight young adults, 5:2 intermittent energy restriction (IER) produces equivalent weight loss and postprandial metabolic responses to continuous energy restriction (CER), but yields superior improvements in fasting blood glucose and fasting subjective appetite scores.

If you are a healthy, normal-weight individual looking to lose weight, 5:2 intermittent fasting is just as effective as eating slightly less every day. You will lose the same amount of weight and see similar improvements in how your body handles food after meals. However, 5:2 fasting may offer a slight edge in lowering your fasting blood sugar and reducing hunger feelings when you wake up, which might help with long-term compliance for some people.

GoodQualifiesHIGH confidence
There were no significant differences in postprandial insulinaemic, glycaemic or appetite responses between treatments. However, 5:2 IER resulted in greater improvements in fasting blood glucose, and beneficial changes in fasting subjective appetite ratings.
Yang-Fan Gao et al. · European Journal of Clinical Nutrition · 2021

Why this rating

Randomized controlled trial with objective metabolic measures, though limited by a small sample size (n=16) and short duration (2 weeks).

Source

Effects of intermittent (5:2) or continuous energy restriction on basal and postprandial metabolism: a randomised study in normal-weight, young participants

Yang-Fan Gao et al. · European Journal of Clinical Nutrition · 2021

DOI 10.1038/s41430-021-00909-2

rct · n=16Cited 31×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →