Research
Energy balance
Very Low Calorie Diet (VLCD) is highly effective for weight loss, producing a mean difference of -4.50 kg compared to eucaloric diet.
VLCD is a highly effective intervention for weight loss, producing a mean loss of 4.5 kg more than eucaloric diet. It should be undertaken with medical supervision due to its intensity.
ModerateSupportsMEDIUM confidence
The very low calorie diet (VLCD) [P=1.00, MD=-4.50 (-5.31, -3.69)]... were significantly more effective than eucaloric diet (UC)
Why this rating
Based on 3 RCTs; consistent results within the network.
Source
Diet Therapeutics Interventions for Obesity: A Systematic Review and Network Meta-Analysis
Mina Morsali et al. · Journal of Research in Health Sciences · 2021
DOI 10.34172/jrhs.2021.63
Meta-analysis · 36 studiesCited 22×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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