Energy balance
Orlistat (360 mg/day) produces significantly greater total body weight loss and fat mass reduction than metformin (1000 mg/day) in obese premenopausal women over 3 months.
If you are an obese premenopausal woman looking to lose weight, orlistat (360mg/day) combined with a balanced diet is likely to produce significantly greater weight loss than metformin (1000mg/day) over a 3-month period. Be prepared for potential gastrointestinal side effects, which are usually mild.
Those treated with orlistat showed greater weight loss (–9.4 ±2.3 vs. –4.9 ±1.3 kg, p < 0.05) and decrease of fat mass (–5.4 ±3.0 vs. –3.5 ±0.7 kg, p < 0.05) than those treated with metformin.
Why this rating
Randomized controlled trial, but open-label and relatively short duration (3 months).
Source
The effect of orlistat versus metformin on body composition and insulin resistance in obese premenopausal women: 3-month randomized prospective open-label study
Magdalena Kujawska-Łuczak et al. · Archives of Medical Science · 2016
DOI 10.5114/aoms.2016.62014
More from this paper
- Metformin (1000 mg/day) produces a greater reduction in android fat mass (kg) compared to orlistat in obese premenopausal women, despite less total weight loss.Good
- Both orlistat and metformin produce comparable improvements in insulin sensitivity (ISI Matsuda) and post-load insulin levels in obese premenopausal women.Good
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