Research
Mixed
Higher AMY1 gene copy number does not significantly modify the risk of cardiovascular disease or mortality associated with starch intake.
You do not need to test your AMY1 gene copy number to determine your starch intake. Standard moderate starch intake recommendations likely apply to you regardless of your genetic makeup regarding amylase.
GoodRefutesHIGH confidence
No significant association was found between AMY1 copy number and risk of CVD and mortality, and there were no interactions between starch intake and AMY1 copy number
Why this rating
Robust genetic analysis (ddPCR) and large sample size for the genetic subset (n=3,932), but null result limits clinical utility.
Source
Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality
Huiping Li et al. · BMC Medicine · 2023
DOI 10.1186/s12916-022-02706-5
cohort · n=21268Cited 6×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High starch intake (top quartile, >28.8 E%) is associated with a significantly higher risk of cardiovascular disease and all-cause mortality compared to moderate intake (22.8-25.3 E%), creating a U-shaped risk curve.Good
- Higher starch intake is associated with lower levels of specific plasma proteins (adrenomedullin, IL1ra, FABP4, leptin, CCL20) that are themselves positively associated with increased CVD and mortality risk.Moderate
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