Research

Macro partitioning

Replacing 5% of daily energy intake from carbohydrates with polyunsaturated fat (PUFA) significantly improves glucose-insulin homeostasis by lowering HbA1c, fasting insulin, and HOMA-IR, and improving insulin secretion capacity.

To improve your blood sugar control and insulin sensitivity, try swapping 5% of your daily calories from carbohydrates (like bread, rice, or sugar) for polyunsaturated fats (found in vegetable oils, nuts, and fish). This specific swap has been shown to lower HbA1c and improve how your pancreas releases insulin. You don't need to eliminate carbs entirely, but prioritizing PUFA over saturated fats or refined carbs when making swaps yields the best metabolic results.

StrongSupportsHIGH confidence
Replacing carbohydrate with PUFA significantly lowered HbA1c (-0.11%; -0.17, -0.05) and fasting insulin (-1.6 pmol/L; -2.8, -0.4). ... Based on gold-standard acute insulin response in ten trials, PUFA significantly improved insulin secretion capacity (+0.5 pmol/L/min; 0.2, 0.8) whether replacing carbohydrate, SFA, or even MUFA.
Fumiaki Imamura et al. · PLoS Medicine · 2016

Why this rating

Systematic review and meta-analysis of 102 randomized controlled feeding trials with 4,220 adults.

Source

Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials

Fumiaki Imamura et al. · PLoS Medicine · 2016

Meta-analysis · 102 studiesCited 487×
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