Research
Hormonal
Semaglutide treatment (1.7-2.4 mg weekly) in patients with hypothalamic obesity secondary to craniopharyngioma produces sustained, clinically significant weight loss (median 16%) and improves metabolic biomarkers (HbA1c, LDL) over 24 months.
For patients with hypothalamic obesity, semaglutide (1.7-2.4 mg weekly) is an effective long-term treatment for weight loss and metabolic health. It is crucial to maintain consistent dosing, as interruptions can lead to fat mass regain. Side effects are generally mild and manageable.
ModerateSupportsMEDIUM confidence
After 24 months, median weight loss was 16% (95% CI: 8 to 34%, p = 0.004)... Hemoglobin A1c and LDL cholesterol declined by 6.4 mmol/mol (95% CI: 2.3 to 9.9, p = 0.016) and 0.5 mmol/L (95% CI: 0.3 to 0.7, p = 0.012).
Why this rating
Small case series (n=4), but with long-term (24 months) follow-up and objective biomarkers.
Source
Semaglutide treatment in hypothalamic obesity: Two-Year outcomes on body composition, appetite, and quality of life
Erlend Gjersdal et al. · Pituitary · 2025
DOI 10.1007/s11102-025-01564-7
case_series · n=4Cited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
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