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Semaglutide treatment significantly reduces emotional and uncontrolled eating scores in patients with hypothalamic obesity, leading to improved quality of life and social functioning.

Semaglutide not only helps with weight loss but also significantly reduces emotional and uncontrolled eating, leading to improved quality of life and social functioning. Patients report feeling more confident and less isolated.

ModerateSupportsMEDIUM confidence
Emotional and uncontrolled eating scores (range: 0–100) decreased by 44 (95% CI: − 69 to − 19, p = 0.011) and 27 units (95% CI: − 63 to 9, p = 0.097), respectively. Interviews revealed reduced hunger, improved self-confidence, less isolation, and higher productivity.
Erlend Gjersdal et al. · Pituitary · 2025

Why this rating

Small case series, but includes qualitative interviews and validated questionnaires.

Source

Semaglutide treatment in hypothalamic obesity: Two-Year outcomes on body composition, appetite, and quality of life

Erlend Gjersdal et al. · Pituitary · 2025

DOI 10.1007/s11102-025-01564-7

case_series · n=4Cited 5×
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DOI resolved against Crossref · corpus check 2026-06-10

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