Mixed
Repeated or substantial weight loss (≥5 kg, especially >10 kg or ≥3 episodes) is associated with significantly increased all-cause and cardiovascular mortality in men, but not in women.
If you are a man, be cautious about repeated, large weight loss cycles (especially >10kg or 3+ times). This study links such patterns to higher heart and overall mortality risk. Women in this study did not show the same risk. Focus on maintaining a stable, healthy weight rather than repeated drastic losses, and consult a doctor if weight loss is unintentional.
We found a 55% (HR 1.55; 95% CI 1.31–1.84) higher rate of all-cause mortality among men with a weight loss > 10 kg... In women, we did neither find a significant association between weight loss of 5 to 10 kg... nor between weight loss of > 10 kg and all-cause mortality
Why this rating
Large prospective cohort (n=34,346), long follow-up (median 20.6 years), linkage to national registries, multivariable adjustment. Limitations include self-reported data and inability to distinguish voluntary vs. involuntary loss.
Source
Prospective study of weight loss and all-cause-, cardiovascular-, and cancer mortality
Liisa Tolvanen et al. · Scientific Reports · 2023
DOI 10.1038/s41598-023-32977-8
More from this paper
- Repeated weight loss (≥3 episodes of ≥5 kg) is associated with increased all-cause and cardiovascular mortality, regardless of the total amount lost in a single episode.Good
- There is no statistically significant association between weight loss (amount or frequency) and cancer mortality in men or women.Good
Related findings · Mixed
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