Research
Hormonal
Sleep deprivation reduces the responsiveness of the circadian clock (SCN) to light, potentially mediated by adenosine blocking glutamate release.
Consistent sleep is required for your body to effectively respond to light cues for resetting your circadian rhythm. Sleep deprivation blunts this response.
GoodSupportsHIGH confidence
Sleep deprivation may reduce the phase-shifting capacity of light by diminishing the strength of the photic signal reaching the SCN, possibly through blocking glutamate release.
Why this rating
Supported by animal studies (mice/hamsters) and human fMRI data.
Source
The two‐process model of sleep regulation: a reappraisal
Alexander A. Borbély et al. · Journal of Sleep Research · 2016
DOI 10.1111/jsr.12371
narrative_reviewCited 1,552×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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