Research
Mixed
Dietary patterns high in fat and carbohydrates exacerbate oxidative stress and inflammation in obese individuals, while antioxidant intake (e.g., fruit) may mitigate lipid peroxidation.
In obesity, both high-fat and high-carb diets can increase oxidative stress. Incorporating fruits and antioxidant-rich foods may help reduce this damage. Focus on reducing processed foods high in both fats and sugars.
ModerateSupportsMEDIUM confidence
A research showed that a diet high in fat and carbohydrates induces a significant increase in OS stress and inflammation in persons with obesity... it was observed that fruit consumption is inversely associated with the level of lipid peroxidation.
Why this rating
Review paper citing observational and interventional studies.
Source
Inflammation, Oxidative Stress, and Obesity
Alba Fernández-Sánchez et al. · International Journal of Molecular Sciences · 2011
DOI 10.3390/ijms12053117
narrative_reviewCited 1,508×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Obesity induces systemic oxidative stress and chronic low-grade inflammation through adipose tissue dysfunction, specifically via increased adipokine secretion (leptin, TNF-α, IL-6) and mitochondrial ROS production, which leads to endothelial dysfunction and insulin resistance.Moderate
- Weight loss reduces circulating levels of pro-inflammatory adipokines (leptin, TNF-α, IL-6) and improves endothelial function, thereby mitigating oxidative stress and cardiovascular risk.Moderate
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