Hormonal

Targeted colonic delivery of propionate via an inulin-propionate ester reduces acute energy intake and prevents long-term weight gain and intra-abdominal fat accumulation in overweight adults.

For overweight adults struggling with gradual weight gain, a specific supplement delivering propionate directly to the colon (10g/day) can help reduce hunger and prevent weight gain over 6 months. It works by triggering satiety hormones (PYY and GLP-1) in the gut. This is distinct from simply eating more fiber, which can cause digestive issues. Consult a doctor before starting, especially if you have liver conditions like NAFLD, as it may also reduce liver fat.