Research

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A higher difference between DNA methylation-predicted age and chronological age (Δage) is associated with a significantly increased risk of all-cause mortality in older adults, independent of known health and lifestyle risk factors.

Your biological age, as measured by DNA methylation patterns, may be a better predictor of your lifespan than your actual age. A higher 'epigenetic age' (meaning your DNA looks older than your chronological age) is linked to a higher risk of death, even if you don't have common diseases like diabetes or high blood pressure. While you cannot directly 'take' this biomarker, the finding suggests that maintaining health through lifestyle factors might help keep your biological age closer to your chronological age, potentially reducing mortality risk.

GoodSupportsHIGH confidence
A 5-year higher Δage is associated with a 21% higher mortality risk, adjusting for age and sex. After further adjustments for childhood IQ, education, social class, hypertension, diabetes, cardiovascular disease, and APOE e4 status, there is a 16% increased mortality risk for those with a 5-year higher Δage.
Riccardo E. Marioni et al. · Genome Biology · 2015

Why this rating

Meta-analysis of four large, independent longitudinal cohorts with robust statistical adjustments for confounders.

Source

DNA methylation age of blood predicts all-cause mortality in later life

Riccardo E. Marioni et al. · Genome Biology · 2015

DOI 10.1186/s13059-015-0584-6

Meta-analysis · 4 studiesCited 1,356×
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DOI resolved against Crossref · corpus check 2026-06-10

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