Mixed
Immunosenescence and inflamm-aging are not merely detrimental processes but are adaptive, energy-conserving mechanisms that support longevity by prioritizing survival over rapid pathogen eradation.
Do not assume that 'boosting' your immune system to youthful levels is always beneficial for longevity. The aging immune system undergoes 'immunoremodeling' to save energy and reduce oxidative stress, which may support a longer life. Focus on maintaining homeostasis and managing inflammation rather than aggressively trying to restore youthful immune metrics.
If one considers these changes from an evolutionary perspective, they can be viewed preferably as adaptive or remodeling rather than solely detrimental... Recent cumulative data suggest that, without the existence of the immunosenescence/inflamm-aging duo (representing two sides of the same phenomenon), human longevity would be greatly shortened.
Why this rating
The paper is a review of observational and longitudinal data (e.g., centenarians) rather than a controlled intervention trial.
Source
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
Tamàs Fülöp et al. · Frontiers in Immunology · 2018
DOI 10.3389/fimmu.2017.01960
Related findings · Mixed
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