Research
Micronutrients & recovery
Selenium's health benefits are mediated by selenoproteins, which are synthesized through a unique mechanism involving the UGA codon and the SECIS element, and these proteins play critical roles in redox regulation, thyroid hormone metabolism, and cancer prevention.
Understanding that selenium works through selenoproteins helps explain why balance is key. Too little selenium means these protective proteins aren't made, while too much can be toxic. Focus on a balanced diet to support your body's natural synthesis of these vital proteins.
GoodSupportsHIGH confidence
Much of its beneficial influence on human health is attributed to its presence within at least 25 proteins, named selenoproteins... The function of most selenoproteins is currently unknown; however, thioredoxin reductases (TrxR), glutathione peroxidases (GPx) and thyroid hormone deiodinases (DIO) are well characterised selenoproteins involved in redox regulation of intracellular signalling, redox homeostasis and thyroid hormone metabolism. Recent evidence points to a role for selenium compounds as well as selenoproteins in the prevention of some forms of cancer.
Why this rating
The paper is a review of molecular mechanisms, citing extensive research on selenoprotein synthesis and function.
Source
From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health
Laura V. Papp et al. · Antioxidants and Redox Signaling · 2007
narrative_reviewCited 1,326×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →