Research
Mixed
Senescent cells contribute to aging and age-related diseases through the Senescence-Associated Secretory Phenotype (SASP), which promotes a pro-inflammatory milieu.
While direct 'senolytic' treatments are not yet standard, lifestyle factors that reduce cellular stress (exercise, healthy diet) may help minimize the accumulation of senescent cells.
GoodSupportsHIGH confidence
Senescent cells increase with age and are considered important contributors to the pro-inflammatory phenotype... The SASP consists of a complex combination of growth factors, proteases, chemokines, matrix metalloproteinases, and is particularly enriched in pro-inflammatory cytokines, especially IL-6.
Why this rating
Strong mechanistic evidence from multiple disease models.
Source
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Irene Maeve Rea et al. · Frontiers in Immunology · 2018
DOI 10.3389/fimmu.2018.00586
narrative_reviewCited 1,257×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Chronic, low-grade inflammation (inflamm-aging) driven by cytokine dysregulation, oxidative stress, and senescent cells is a primary mechanism underlying aging and age-related diseases such as cardiovascular disease, diabetes, and neurodegeneration.Good
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