Mixed
Composite biomarker predictors, which combine multiple clinical and biochemical markers (e.g., CRP, creatinine, blood pressure), are effective biological age predictors that correlate with mortality, physical function, and cognitive decline, often outperforming single biomarkers like telomere length.
Composite biomarker scores, which combine multiple blood tests and clinical measures (like blood pressure and cholesterol), are powerful tools for assessing biological age. They often predict health outcomes and mortality better than single markers. While more complex to obtain, they provide a more comprehensive view of your systemic health than a single test, helping to identify risks that might be missed by looking at one factor alone.
Health outcomes such as IQ and physical function measured in the Dunedin participants seem to be best predicted by the composite biomarker age, then by DNAmAge and not at all by telomere length.
Why this rating
Validated in large cohorts (NHANES III, Dunedin), but models vary between studies (Levine vs. Sebastiani), limiting direct comparison.
Source
Biological Age Predictors
Juulia Jylhävä et al. · EBioMedicine · 2017
DOI 10.1016/j.ebiom.2017.03.046
More from this paper
- Epigenetic clocks (DNAmAge) are currently the most robust biological age predictors, strongly correlating with chronological age and independently predicting all-cause mortality, cancer mortality, and various aging phenotypes such as frailty and cognitive decline.Good
- Telomere length is a valid biological age predictor that correlates with mortality, particularly for cancer and cardiovascular disease, and is independent of epigenetic clocks, though its predictive power varies by cancer type and sex.Moderate
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