Research
Energy balance
Leptin-replacement therapy reduces daily caloric intake and resting metabolic rate in patients with lipodystrophy.
Leptin therapy naturally reduces hunger and metabolic rate in these patients, contributing to weight loss and metabolic improvement.
GoodSupportsHIGH confidence
Self-reported daily caloric intake and the measured resting metabolic rate also decreased significantly with therapy.
Why this rating
Small sample size but statistically significant results.
Source
Leptin-Replacement Therapy for Lipodystrophy
Elif A Oral et al. · New England Journal of Medicine · 2002
DOI 10.1056/nejmoa012437
clinical_trial · n=9Cited 1,233×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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