Research
Hormonal
In young obese subjects, lower fecal Escherichia coli abundance is associated with higher serum lipopolysaccharide (LPS) levels, indicating that reduced E. coli may increase the risk of metabolic endotoxemia.
If you are obese, having very low levels of E. coli in your gut might actually be a risk factor for metabolic issues like inflammation, rather than a benefit. This suggests that simply trying to eliminate all bacteria is not the right approach; maintaining a balanced microbiome is key.
ModerateQualifiesMEDIUM confidence
A decrease of E. coli was associated with an increased risk of lipopolysaccharide levels ranging from 1 to 1.3 EU/ml.
Why this rating
Observational study with a small sample size (n=64) and cross-sectional design; cannot establish causality.
Source
Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects
Romina Belén Radilla-Vázquez et al. · Obesity Facts · 2016
DOI 10.1159/000442479
cross_sectional · n=64Cited 1,198×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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