Research
Energy balance
Activation of PPARβ/δ promotes fatty acid oxidation in skeletal and cardiac muscles, preventing obesity and protecting the heart from ischemia-reperfusion injury, particularly in the context of high-fat diets.
Regular exercise, particularly in skeletal and cardiac muscles, may upregulate PPARβ/δ, enhancing the body's ability to burn fatty acids and resist obesity, even with higher fat intake.
ModerateSupportsMEDIUM confidence
PPARβ/δ participates in fatty acid oxidation, mostly in skeletal and cardiac muscles... overexpression of PPARβ/δ prevents the development of obesity and reduces lipid accumulation in cardiac cells, even during a high-fat diet.
Why this rating
Based on animal models and in vitro studies; clinical data for specific PPARβ/δ agonists is less extensive than for α/γ.
Source
Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review
Bogna Grygiel‐Górniak · Nutrition Journal · 2014
DOI 10.1186/1475-2891-13-17
narrative_reviewCited 1,191×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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