Hormonal
Long-term consumption of a high-fat diet induces local proinflammatory signaling (TNF-alpha, IL-1beta, JNK, NF-kB) in the hypothalamus, which directly causes insulin resistance and impairs the brain's ability to regulate food intake and energy expenditure.
Eating a diet very high in fat can trigger inflammation in the brain's hunger-control center (hypothalamus). This inflammation blocks insulin's ability to tell your brain you are full, leading to overeating and weight gain. Reducing high-fat intake may help reduce this brain inflammation and restore normal hunger signals.
We conclude that HL feeding induces a local proinflammatory status in the hypothalamus, which results in impaired anorexigenic insulin signaling.
Why this rating
High-quality animal study with clear mechanistic pathways and functional outcomes, though not directly translatable to human clinical trials without further validation.
Source
Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus
Cláudio Teodoro de Souza et al. · Endocrinology · 2005
DOI 10.1210/en.2004-1520
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