Hormonal
Inhibiting the inflammatory enzyme JNK in the hypothalamus restores insulin signaling, reduces caloric intake, and promotes weight loss in subjects consuming a high-fat diet.
This study used a specific drug (SP600125) to block an inflammatory enzyme in the brain of rats. While this restored weight loss, this is a research tool and not a recommended supplement for humans. The finding suggests that managing brain inflammation might be key to treating obesity.
Intracerebroventricular treatment of HL rats with a specific inhibitor of c-Jun N-terminal kinase (SP600125) restores insulin signaling and leads to a reduced caloric intake and weight loss.
Why this rating
Strong mechanistic evidence in animal models showing causal link between JNK inhibition and metabolic improvement.
Source
Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus
Cláudio Teodoro de Souza et al. · Endocrinology · 2005
DOI 10.1210/en.2004-1520
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