Research

Energy balance

Acute negative energy balance via a very-low-energy diet (approx. 600 kcal/day) reverses type 2 diabetes by normalizing beta-cell function and hepatic insulin sensitivity, associated with a rapid reduction in liver and pancreatic fat.

If you have recently been diagnosed with type 2 diabetes, your condition may not be permanent. This study suggests that adopting a strict, very-low-calorie diet (around 600 calories per day, supervised) can rapidly reduce fat in your liver and pancreas, potentially restoring your body's ability to regulate blood sugar and insulin normally. This is not a standard weight-loss diet but a specific medical intervention that should be undertaken with professional supervision.

GoodSupportsHIGH confidence
This study demonstrates that the twin defects of beta cell failure and insulin resistance that underlie type 2 diabetes can be reversed by acute negative energy balance alone... The data are consistent with the hypothesis that the abnormalities of insulin secretion and insulin resistance that underlie type 2 diabetes have a single, common aetiology, i.e. excess lipid accumulation in the liver and pancreas.
Ee Lin Lim et al. · Diabetologia · 2011

Why this rating

Small sample size (n=11) and short duration (8 weeks), but uses gold-standard metabolic clamps and MRI.

Source

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

Ee Lin Lim et al. · Diabetologia · 2011

DOI 10.1007/s00125-011-2204-7

clinical_trial · n=19Cited 1,150×
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DOI resolved against Crossref · corpus check 2026-06-10

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