Hormonal
Surgery-induced weight loss in morbidly obese subjects significantly reduces the number of macrophages infiltrating subcutaneous white adipose tissue (scWAT) and shifts their phenotype from pro-inflammatory to anti-inflammatory (IL10-positive).
For morbidly obese individuals, significant weight loss (achieved here via surgery) actively reduces inflammation in fat tissue. It doesn't just remove fat; it changes the immune environment of the fat, turning harmful inflammatory cells into less harmful ones. This suggests that weight loss has direct anti-inflammatory benefits beyond just lowering body weight.
Drastic weight loss resulted in a significant decrease in macrophage number (-11.63 +/- 2.3%, P < 0.001), and remaining macrophages stained positive for the anti-inflammatory protein interleukin 10.
Why this rating
Small sample size (n=17) but rigorous histological and molecular validation (immunohistochemistry, microarray, RTqPCR).
Source
Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss
Raffaella Cancello et al. · Diabetes · 2005
DOI 10.2337/diabetes.54.8.2277
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