Research
Hormonal
Weight loss reduces the expression of genes involved in macrophage recruitment (MCP-1, CSF-3, PLAUR) and hypoxia (HIF-1) in the stroma vascular fraction of white adipose tissue.
Obesity causes fat tissue to produce signals (like MCP-1 and HIF-1) that attract inflammatory cells. Losing weight reduces these signals, thereby stopping the recruitment of new inflammatory cells to fat tissue.
GoodSupportsHIGH confidence
Genes involved in macrophage attraction (monocyte chemotactic protein [MCP]-1, plasminogen activator urokinase receptor [PLAUR], and colony-stimulating factor [CSF]-3) and hypoxia (hypoxia-inducible factor-1alpha [HIF-1alpha]), expression of which increases in obesity and decreases after surgery, were predominantly expressed in the SVF.
Why this rating
Validated by RTqPCR and microarray analysis, though sample size for gene expression subset was smaller (n=10).
Source
Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss
Raffaella Cancello et al. · Diabetes · 2005
DOI 10.2337/diabetes.54.8.2277
cohort · n=24Cited 1,149×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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