Mixed
Phytochemicals provide health benefits through specific biochemical mechanisms, but efficacy must be demonstrated in vivo, as in vitro and animal studies alone are insufficient to claim disease prevention in humans.
Do not rely on isolated phytochemical supplements to treat or prevent disease based solely on lab studies. While plant compounds like polyphenols and terpenes have known mechanisms (e.g., antioxidant, anti-inflammatory), their actual benefit in humans depends on absorption and metabolism. Focus on whole food sources (fruits, vegetables, grains) rather than isolated extracts, as the synergy and bioavailability in whole foods are better understood than in isolated nutraceuticals.
Mechanisms of action must certainly be established in vitro; however, the efficacy of these same ingredients with their mechanisms of action, must also be demonstrated in vivo.
Why this rating
High-quality review paper synthesizing extensive literature, though it highlights the lack of definitive human clinical trials for many compounds.
Source
Phytochemicals: nutraceuticals and human health
Cora J. Dillard et al. · Journal of the Science of Food and Agriculture · 2000
DOI 10.1002/1097-0010(20000915)80:12<1744::aid-jsfa725>3.0.co;2-w
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