Research
Macro partitioning
High-fat diets and saturated fatty acids can disrupt intestinal barrier integrity and promote systemic inflammation via TLR4 activation and bile acid alterations.
Limiting saturated fat intake and focusing on unsaturated fats can help maintain gut barrier integrity and reduce systemic inflammation, especially in individuals prone to metabolic issues.
GoodSupportsHIGH confidence
TLR4 can be stimulated also by saturated fatty acids (SFA), showing an important role of high-fat diet itself in determining systemic inflammation. This binding could depend on a structural similarity between dietary SFA and the Lipid A of LPS...
Why this rating
Supported by mechanistic studies and animal models cited in the review.
Source
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
Federica Di Vincenzo et al. · Internal and Emergency Medicine · 2023
DOI 10.1007/s11739-023-03374-w
narrative_reviewCited 1,087×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Intestinal barrier disruption (leaky gut) allows translocation of bacterial endotoxins like LPS into circulation, driving systemic low-grade inflammation and contributing to metabolic and autoimmune diseases.Good
- Specific gut microbiota species and their metabolites (SCFAs, bile acids) actively maintain intestinal barrier integrity and exert anti-inflammatory effects.Good
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