Research
Macro partitioning
High-fat diets and saturated fatty acids can disrupt intestinal barrier integrity and promote systemic inflammation via TLR4 activation and bile acid alterations.
Limiting saturated fat intake and focusing on unsaturated fats can help maintain gut barrier integrity and reduce systemic inflammation, especially in individuals prone to metabolic issues.
GoodSupportsHIGH confidence
TLR4 can be stimulated also by saturated fatty acids (SFA), showing an important role of high-fat diet itself in determining systemic inflammation. This binding could depend on a structural similarity between dietary SFA and the Lipid A of LPS...
Why this rating
Supported by mechanistic studies and animal models cited in the review.
Source
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
Federica Di Vincenzo et al. · Internal and Emergency Medicine · 2023
narrative_reviewCited 1,087×
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