Mixed
Intestinal barrier disruption (leaky gut) allows translocation of bacterial endotoxins like LPS into circulation, driving systemic low-grade inflammation and contributing to metabolic and autoimmune diseases.
Maintaining gut barrier integrity through a diverse, fiber-rich diet supports the production of short-chain fatty acids (SCFAs) and healthy microbiota, which are critical for preventing the translocation of inflammatory bacterial components like LPS. This is a foundational aspect of metabolic and immune health, not just digestive comfort.
Disruption of the barrier is referred to as 'leaky gut' or leaky gut wall syndrome and seems to be characterized by the release of bacterial metabolites and endotoxins, such as lipopolysaccharide (LPS), into the circulation. This condition... appear to be highly connected with the development and/or progression of several metabolic and autoimmune systemic diseases, including obesity, non-alcoholic fatty liver disease (NAFLD)... and type 1 diabetes mellitus (T1D).
Why this rating
Narrative review citing multiple human and animal studies, but lacks a single large-scale clinical trial.
Source
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
Federica Di Vincenzo et al. · Internal and Emergency Medicine · 2023
DOI 10.1007/s11739-023-03374-w
More from this paper
- Specific gut microbiota species and their metabolites (SCFAs, bile acids) actively maintain intestinal barrier integrity and exert anti-inflammatory effects.Good
- High-fat diets and saturated fatty acids can disrupt intestinal barrier integrity and promote systemic inflammation via TLR4 activation and bile acid alterations.Good
Related findings · Mixed
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