Mixed

High levels of Reactive Oxygen Species (ROS) are causally linked to the induction and maintenance of cell senescence, which drives aging and age-related diseases, whereas low ROS levels are associated with extended organismal lifespan.

Focus on maintaining natural redox balance rather than relying on high-dose antioxidant supplements, which may be ineffective or harmful. The paper highlights that moderate ROS levels (e.g., from exercise) can be beneficial (mitohormesis), while chronic high ROS (from stress, smoking, poor diet) drives aging. Strategies like caloric restriction and exercise are mentioned as ways to reduce OS and extend lifespan.