Hormonal
The addition of orlistat or sibutramine to a weight maintenance diet is associated with significant weight loss and generally improved cardiovascular risk factors in adults with obesity.
If you have obesity, adding orlistat or sibutramine to a weight maintenance diet can help you lose about 3-3.4 kg over 1.5-2 years and improve risk factors like cholesterol, though sibutramine may not help diastolic blood pressure.
The addition of the drugs orlistat or sibutramine was associated with weight loss and generally improved risk factors, apart from diastolic blood pressure for sibutramine.
Why this rating
Based on systematic review of RCTs with follow-up of at least 1 year, though the authors note limitations in sample size and long-term follow-up.
Source
Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement
Alison Avenell et al. · Health Technology Assessment · 2004
DOI 10.3310/hta8210
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