Mixed
Regular use of fish oil and glucosamine supplements is associated with reduced all-cause and cancer mortality in cancer patients, but this benefit is conditional on having a low Life Essential 8 (LE8) score or a poor cancer prognosis.
If you have cancer, taking fish oil or glucosamine may help reduce your risk of death, but only if your overall cardiovascular health (LE8 score) is below average or your specific cancer type has a poor prognosis. For patients with high cardiovascular health scores or good-prognosis cancers, these supplements did not show a significant mortality benefit in this study. Always consult your oncologist before starting supplements.
Subgroup analyses revealed that the protective effects of fish oil and glucosamine against mortality risk were only observed in patients with LE8 scores lower than the mean score or a poor cancer prognosis.
Why this rating
Large prospective cohort (UK Biobank, n=14,920), long follow-up (median 12 years), fully adjusted models, but observational design limits causal inference.
Source
Association between fish oil and glucosamine use and mortality in patients diagnosed with cancer: the role of the Life Essential 8 score and cancer prognosis
Chun Sing Lam et al. · Nutrition Journal · 2024
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