Mixed
High-throughput quantitative serum NMR metabolomics provides a cost-effective, automated method to profile over 200 molecular measures (lipoprotein subclasses, fatty acids, amino acids) from a single sample, enabling large-scale epidemiological risk assessment comparable to standard lipid measurements.
For researchers and clinicians, adopting high-throughput NMR metabolomics allows for the routine, cost-effective assessment of detailed metabolic health (lipoprotein subclasses, amino acids) from standard blood samples. This provides a more nuanced view of cardiovascular and metabolic risk than traditional lipid panels alone, without significantly increasing cost or complexity due to automation.
Our team has developed an automated high-throughput serum NMR metabolomics platform that provides quantitative molecular data on 14 lipoprotein subclasses... The molar concentrations of these measures are obtained from a single serum sample with costs comparable to standard lipid measurements.
Why this rating
Based on the analysis of ~250,000 samples across ~100 cohorts, providing robust statistical power for biomarker discovery.
Source
Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
Pasi Soininen et al. · Circulation Cardiovascular Genetics · 2015
DOI 10.1161/circgenetics.114.000216
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →