Research

Mixed

High-throughput quantitative serum NMR metabolomics provides a cost-effective, automated method to profile over 200 molecular measures (lipoprotein subclasses, fatty acids, amino acids) from a single sample, enabling large-scale epidemiological risk assessment comparable to standard lipid measurements.

For researchers and clinicians, adopting high-throughput NMR metabolomics allows for the routine, cost-effective assessment of detailed metabolic health (lipoprotein subclasses, amino acids) from standard blood samples. This provides a more nuanced view of cardiovascular and metabolic risk than traditional lipid panels alone, without significantly increasing cost or complexity due to automation.

GoodSupportsHIGH confidence
Our team has developed an automated high-throughput serum NMR metabolomics platform that provides quantitative molecular data on 14 lipoprotein subclasses... The molar concentrations of these measures are obtained from a single serum sample with costs comparable to standard lipid measurements.
Pasi Soininen et al. · Circulation Cardiovascular Genetics · 2015

Why this rating

Based on the analysis of ~250,000 samples across ~100 cohorts, providing robust statistical power for biomarker discovery.

Source

Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics

Pasi Soininen et al. · Circulation Cardiovascular Genetics · 2015

DOI 10.1161/circgenetics.114.000216

narrative_review · n=250000Cited 1,001×
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DOI resolved against Crossref · corpus check 2026-06-10

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