Mixed
Dietary cholesterol intake between 216 and 373 mg/day is associated with the lowest all-cause mortality risk, forming a U-shaped curve where both lower and higher intakes increase mortality risk.
Aim for a daily dietary cholesterol intake of approximately 300 mg (roughly 1-2 eggs) to potentially minimize all-cause mortality risk. Avoid both very low intake (under 124 mg/day) and very high intake (over 373 mg/day), as both are associated with higher mortality risks in this study. This suggests that moderate consumption of cholesterol-rich foods is healthy, and extreme restriction may be detrimental.
The association between cholesterol intake and the risk of all-cause mortality followed a U-shaped curve, with the cholesterol intake associated with the lowest mortality being 328 mg/day.
Why this rating
Observational cohort study using NHANES data; adjusted for many covariates but subject to residual confounding and reverse causality.
Source
Association between cholesterol intake and all-cause mortality: NHANES-linked mortality study
Xiang-Peng Du et al. · Central European Journal of Public Health · 2021
DOI 10.21101/cejph.a6276
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