Energy balance
Two-year treatment with orlistat (120 mg three times daily) combined with a controlled-energy diet produces significantly greater sustained weight loss and reduces weight regain compared to placebo plus diet in obese adults.
To sustain weight loss over two years, obese individuals should take 120 mg of orlistat with each of their three main meals while following a controlled-energy diet where 30% of calories come from fat. This combination leads to significantly greater weight loss and less weight regain compared to diet and placebo alone. Be prepared for potential gastrointestinal side effects if fat intake is not strictly managed, as these are expected but usually mild and resolve over time.
Two-year treatment with orlistat plus diet significantly promotes weight loss, lessens weight regain, and improves some obesity-related disease risk factors.
Why this rating
Large-scale (n=880 intent-to-treat), randomized, double-blind, placebo-controlled trial with 2-year duration.
Source
Weight Control and Risk Factor Reduction in Obese Subjects Treated for 2 Years With Orlistat
Michael Davidson et al. · JAMA · 1999
DOI 10.1001/jama.281.3.235
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