Research
Hormonal
Higher red blood cell membrane levels of n-3 polyunsaturated fatty acids (specifically 5.0% of total fatty acids) are associated with a 70% reduction in the risk of primary cardiac arrest compared to lower levels (3.3%).
Maintaining higher levels of n-3 fatty acids in your red blood cell membranes (around 5.0% of total fatty acids) is associated with a significantly lower risk of primary cardiac arrest. This biomarker reflects consistent dietary intake of fatty fish.
GoodSupportsHIGH confidence
Compared with a red blood cell membrane n-3 polyunsaturated fatty acid level of 3.3% of total fatty acids (the mean of the lowest quartile), a red blood cell n-3 polyunsaturated fatty acid level of 5.0% of total fatty acids (the mean of the third quartile) was associated with a 70% reduction in the risk of primary cardiac arrest (OR, 0.3; 95% CI, 0.2 to 0.6).
Why this rating
Strong biomarker validation supports the dietary findings, though the observational nature remains a limitation.
Source
Dietary Intake and Cell Membrane Levels of Long-Chain n-3 Polyunsaturated Fatty Acids and the Risk of Primary Cardiac Arrest
David S. Siscovick · JAMA · 1995
DOI 10.1001/jama.1995.03530170043030
case_control · n=827Cited 897×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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