Hormonal
Testosterone replacement therapy (200 mg testosterone cypionate biweekly) significantly improves upper body strength (grip strength) in older hypogonadal men over a 12-month period.
If you are an older man with clinically low testosterone, testosterone replacement therapy can significantly improve your hand grip strength, which is a key indicator of physical function and frailty. This benefit was observed over a year of treatment. However, you must be monitored for side effects like high red blood cell counts.
Testosterone significantly increased upper body strength as measured by grip strength (P < 0.05)... The delta mean right and left grip strength at 3, 6, and 9 months and delta mean left grip strength at 12 months were all significant (P < 0.05).
Why this rating
Randomized controlled trial with a control group, though limited by a small sample size (n=17 treatment) and significant dropout rate.
Source
Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial
Rahmawati Sih et al. · The Journal of Clinical Endocrinology & Metabolism · 1997
DOI 10.1210/jcem.82.6.3988
More from this paper
- Testosterone replacement therapy significantly decreases serum leptin levels in older hypogonadal men, suggesting a hormonal modulation of adiposity regulation.Good
- Testosterone replacement therapy increases hemoglobin and hematocrit levels in older hypogonadal men, requiring monitoring for polycythemia.Good
- Testosterone replacement therapy has no significant effect on memory, cognitive function, or prostate-specific antigen (PSA) levels in older hypogonadal men over 12 months.Good
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