Hormonal
Testosterone replacement therapy significantly decreases serum leptin levels in older hypogonadal men, suggesting a hormonal modulation of adiposity regulation.
Testosterone therapy in hypogonadal men has been shown to lower leptin levels, a hormone involved in regulating body fat and hunger. This suggests testosterone may help modulate body composition, although this study did not show significant changes in body fat percentage or BMI.
Testosterone significantly decreased leptin levels (control, delta -0.8 +/- 0.7 ng/dL; testosterone, delta -2.0 +/- 0.9 ng/dL; P < 0.02).
Why this rating
RCT design with clear statistical significance, though the clinical relevance of leptin reduction alone is less defined than strength gains.
Source
Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial
Rahmawati Sih et al. · The Journal of Clinical Endocrinology & Metabolism · 1997
DOI 10.1210/jcem.82.6.3988
More from this paper
- Testosterone replacement therapy (200 mg testosterone cypionate biweekly) significantly improves upper body strength (grip strength) in older hypogonadal men over a 12-month period.Good
- Testosterone replacement therapy increases hemoglobin and hematocrit levels in older hypogonadal men, requiring monitoring for polycythemia.Good
- Testosterone replacement therapy has no significant effect on memory, cognitive function, or prostate-specific antigen (PSA) levels in older hypogonadal men over 12 months.Good
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