Macro partitioning
Dietary fats modulate postprandial inflammation and metabolic risk, with long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) attenuating adipose inflammation and restoring endogenous anti-inflammatory lipid mediators (resolvins/protectins) in obese individuals, whereas saturated fatty acids (SFA) may promote pro-inflammatory states via inflammasome activation.
Focus on the quality of your dietary fats rather than just reducing total fat. Incorporate sources of long-chain n-3 polyunsaturated fatty acids (like fatty fish) to help reduce inflammation and improve metabolic health, especially if you have excess body weight. Be mindful that high intake of saturated fats may promote inflammatory pathways, but the impact can vary based on individual genetics and overall diet context.
dietary EPA/DHA supplementation within an obesogenic dietary challenge restored endogenous adipose resolvin and protectin bio-synthesis, concomitant with attenuated adipose inflammation and insulin resistance
Why this rating
Supported by human RCTs (e.g., LIPGENE, obese patient studies) and mechanistic data, though some fasting biomarker results are inconsistent.
Source
Low-grade inflammation, diet composition and health: current research evidence and its translation
Anne Marie Minihane et al. · British Journal Of Nutrition · 2015
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