Research
Micronutrients & recovery
Gut microbiota-derived lipopolysaccharides (LPS) contribute to systemic low-grade inflammation (metabolic endotoxemia) through increased gut permeability, particularly in contexts of aging, obesity, and high-fat diets, triggering Toll-like receptor 4 activation and subsequent inflammatory responses.
Support your gut barrier by consuming diets rich in fermentable fibers and whole plant foods. This helps maintain a healthy microbiome, which can reduce gut permeability and lower the risk of systemic inflammation triggered by bacterial products like LPS.
GoodSupportsHIGH confidence
microbiota-derived LPS may be an important trigger in the development of inflammation and metabolic diseases
Why this rating
Strong mechanistic evidence from animal models and human observational data linking LPS to inflammation.
Source
Low-grade inflammation, diet composition and health: current research evidence and its translation
Anne Marie Minihane et al. · British Journal Of Nutrition · 2015
DOI 10.1017/s0007114515002093
narrative_reviewCited 887×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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