Research
Hormonal
The metabolic effects of IL-6 on glucose uptake and fatty acid oxidation in skeletal muscle are mediated by the activation of AMP-activated protein kinase (AMPK), as evidenced by the abrogation of these effects in cells with dominant-negative AMPK.
AMPK activation is a key pathway through which exercise-induced signals improve metabolism. Strategies that activate AMPK (like exercise itself) leverage this pathway to enhance glucose and fat handling.
StrongSupportsVERY_HIGH confidence
The effects described above were abrogated in AMPK dominant-negative–infected cells.
Why this rating
The use of dominant-negative AMPK constructs provides definitive causal evidence for the mechanism in vitro.
Source
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Andrew L. Carey et al. · Diabetes · 2006
DOI 10.2337/db05-1404
crossover · n=7Cited 880×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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