Research
Hormonal
Deiodinase activity is regulated by a variety of endogenous signaling molecules and xenobiotics, including hypoxia-inducible factor-1, growth factors, and bile acids.
Your thyroid hormone metabolism isn't just controlled by the thyroid gland; it's influenced by your body's response to stress, hypoxia, and other signals like growth factors and bile acids.
GoodSupportsMEDIUM confidence
deiodinase expression can be modulated by a wide variety of endogenous signaling molecules such as sonic hedgehog, nuclear factor-(cid:1)B, growth factors, bile acids, hypoxia-inducible factor-1(cid:2), as well as a growing number of xenobiotic substances.
Why this rating
Listed as a summary of recent findings in a review article.
Source
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
Balázs Gereben et al. · Endocrine Reviews · 2008
DOI 10.1210/er.2008-0019
narrative_reviewCited 868×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Type 2 deiodinase (D2) and Type 3 deiodinase (D3) locally regulate thyroid hormone signaling within specific tissues independently of serum thyroid hormone concentrations.Strong
- Type 2 deiodinase (D2) is retained in the endoplasmic reticulum (ER), allowing locally generated T3 to have prolonged access to nuclear thyroid hormone receptors compared to T3 entering from the plasma.Strong
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